Formulation, Development and Characterization of Nanostructured Lipid Carrier (NLC) Loaded Gel for Psoriasis. Shinde, G., Rajesh, KS., Prajapati, N., Murthy, RSR., 2013. Asian J Pharm Clinical Res, Vol 10, Issue 2, 2017, 1-7. Effectivity and physicochemical stability of nanostructured lipid carrier coenzyme Q10 in different ratio of lipid cetyl palmitate and alpha tocopheryl acetate as carrier. Putranti, AR., primaharinastiti, R., Hendradi, E., 2017. Development and evaluation of nanostructured Lipid Carrier (NLC) Based Topical Delivery of an Anti-Inflammatory Drug. Nano-structured Lipid Carriers (NLC)-Based Gel for the Topical Delivery of Aceclofenac: Preparation, Charac-terization, and In Vivo Evaluation. Patel, D., Dasgupta, S., Dey, S., Ramani, Y. Novel Formulation Approaches for Dermal and Transdermal Delivery of Non-Steroidal Anti-Inflamatory Drugs. Solid Lipid Nanoparticles and Nano Structure Carriers : An Overview. Meghana, SK., Vaidya, KK., Bhosale, AV., Chaundari, PD., 2012. Topical Preparations for Pain Relief: Efficacy and Patient Adherence.

Effect of Oleic Acid on the Permeation Kinetics of Diclofenac Diethylamine. Hussain Shah, SN., Salman, M., Ahmad, M., 2012. Farmakologi dan Terapi, Edisi 5, Jakarta: Balai Penerbit FKUI, hal 230-233. Gunawan, SG., Setiabudy, R., Nafrialdi, & Elysabeth., 2007. Effect of the Counterions on the Permeation through Porcine Membrane from Aqueous Saturated Solutions. Physical and chemical characteristics of meloxicam from nanostructured lipid carriers system using some concentration ratios of monostearin and alpha-tocopherol acetate lipid matrix. Increasing the amount of liquid lipid in the formulations reduced the size of NLC-DETA particles.Īnggraeni, Y., Haryanto, IY., Hendradi, E., 2017. On the other hand, it affected the pH of all formulas, which were significantly different. The results showed that the different ratios of oleic acid lipids and stearic acid had no significant effects on the viscosity and entrapment efficiency of NLC-DETA. The particle shape and morphology were determined by Transmission Electron Microscopy (TEM).

NLC were characterized for organoleptic characteristics, pH, viscosity, particle morphology, particle size and polydispersity index (PI), profiles of Fourier Transform Infra-Red (FTIR) and Differential Thermal Analysis (DTA), and drug entrapment efficiency. In this NLC system, DETA served as the active drug, stearic acid as solid lipid, oleic acid as liquid lipid, and Tween 80 as surfactant components. In the formulation of NLC-DETA, three different lipid ratios were used, which the ratio of stearic acid:oleic acid were 60:40, 70:30, and 80:20, respectively. Diethylammonium diclofenac (DETA) is Non-Steroid Anti-Inflamatory Drugs (NSAIDs) that has been widely used in the treatment of osteoarthritis and rheumatoid arthritis. The aim of this study was to determine the effect of lipid ratio of stearic acid and oleic acid on the physical characteristics as well as the entrapment efficiency of diethylammonium diclofenac with Nanostructure Lipid Carrier (NLC) system.

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